Variation of DNA photocleavage efficiency for [(TL)2Ru(dpp)]Cl2 complexes where TL = 2,2′-bipyridine, 1,10-phenanthroline, or 4,7-diphenyl-1,10-phenanthroline

Matthew T. Mongelli, Julie Heinecke, Shatara Mayfield, Benjamin Okyere, Brenda S.J. Winkel, Karen J. Brewer

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The complexes [(bpy)2Ru(dpp)]Cl2, [(phen)2Ru(dpp)]Cl2, and [(Ph2phen)2Ru(dpp)]Cl2 (where dpp = 2,3-bis(2-pyridyl)pyrazine, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, Ph2phen = 4,7-diphenyl-1,10-phenanthroline) have been investigated and found to photocleave DNA via an oxygen-mediated pathway. These light absorbing complexes possess intense metal-to-ligand charge transfer (MLCT) transitions in the visible region of the spectrum. The [(TL)2Ru(dpp)]2+ systems populate 3MLCT states after visible light excitation, giving rise to emissions in aqueous solution centered at 692, 690, and 698 nm for TL = bpy, phen, and Ph2phen respectively. The 3MLCT states and emissions are quenched by O2, producing a reactive oxygen species. These complexes photocleave DNA with varying efficiencies, [(Ph2phen)2Ru(dpp)]2+ > [(phen)2Ru(dpp)]2+ > [(bpy)2Ru(dpp)]2+. The presence of the polyazine bridging ligand will allow these chromophores to be incorporated into larger supramolecular assemblies.

Original languageEnglish
Pages (from-to)1983-1987
Number of pages5
JournalJournal of Inorganic Biochemistry
Volume100
Issue number12
DOIs
StatePublished - Dec 2006

Keywords

  • DNA interactions
  • Emission spectroscopy
  • Photocleavage
  • Polyazine bridging ligand
  • Ruthenium complexes

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