The chiral separation and enantioselective degradation of the chiral herbicide napropamide

Yanli Qi, Donghui Liu, Mingjing Sun, Shanshan Di, Peng Wang, Zhiqiang Zhou

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The chiral pesticide enantiomers often have different toxic effects and environmental behaviors, which suggests that the risk assessments should be on an enantiomeric level. In this work, the chiral separation of the napropamide enantiomers and the stereoselective degradation in tomato, cucumber, rape, cabbage, and soil were investigated. Napropamide enantiomers could be separated absolutely by high-performance liquid chromatography (HPLC) using a Chiralpak IC column with a resolution factor of 11.75 under the optimized condition. Solid phase extraction (SPE) was used for cleanup of the enantiomers in the vegetable samples. The residue analysis method was validated. Good linearities (R 2 = 0.9997) and recoveries (71.43% -97.64%) were obtained. The limits of detection (LOD) were 0.05 mg/kg in soil and 0.20 mg/kg in vegetables. The results of degradation showed that napropamide dissipated rapidly in vegetables with half-lives of only 1.13-2.21 days, but much more slowly in soil, with a half-life of 11.95 d. Slight stereoselective degradation of the two enantiomers was only observed in cabbage, with enantiomeric fraction (EF) = 0.46, and there was no enantioselectivity in the other vegetables. The degradation of napropamide in the five matrixes was fast, and there was no enantioselectivity.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalChirality
Volume26
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • chiral separation
  • enantioselective degradation
  • napropamide

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