Tailored Solid-State Carbohydrate Nanostructures Based on Star-Shaped Discrete Block Co-Oligomers

Takuya Isono; Ryoya Komaki; Nao Kawakami; Kai Chen; Hsin Lung Chen; Chaehun Lee; Kazushige Suzuki; Brian J. Ree; Hiroaki Mamiya; Takuya Yamamoto; Redouane Borsali; Kenji Tajima; Toshifumi Satoh

doi:10.1021/acs.biomac.2c00813

Tailored Solid-State Carbohydrate Nanostructures Based on Star-Shaped Discrete Block Co-Oligomers

Takuya Isono, Ryoya Komaki, Nao Kawakami, Kai Chen, Hsin Lung Chen, Chaehun Lee, Kazushige Suzuki, Brian J. Ree, Hiroaki Mamiya, Takuya Yamamoto, Redouane Borsali, Kenji Tajima, Toshifumi Satoh

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Carbohydrates are key building blocks for advanced functional materials owing to their biological functions and unique material properties. Here, we propose a star-shaped discrete block co-oligomer (BCO) platform to access carbohydrate nanostructures in bulk and thin-film states via the microphase separation of immiscible carbohydrate and hydrophobic blocks (maltooligosaccharides with 1-4 glucose units and solanesol, respectively). BCOs with various star-shaped architectures and saccharide volume fractions were synthesized using a modular approach. In the bulk, the BCOs self-assembled into common lamellar, cylindrical, and spherical carbohydrate microdomains as well as double gyroid, hexagonally perforated lamellar, and Fddd network morphologies with domain spacings of ∼7 nm. In thin films, long-range-ordered periodic carbohydrate microdomains were fabricated via spin coating. Such controlled spatial arrangements of functional carbohydrate moieties on the nanoscale have great application potential in biomedical and nanofabrication fields.

Original language	English
Pages (from-to)	3978-3989
Number of pages	12
Journal	Biomacromolecules
Volume	23
Issue number	9
DOIs	https://doi.org/10.1021/acs.biomac.2c00813
State	Published - 12 Sep 2022

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title = "Tailored Solid-State Carbohydrate Nanostructures Based on Star-Shaped Discrete Block Co-Oligomers",

abstract = "Carbohydrates are key building blocks for advanced functional materials owing to their biological functions and unique material properties. Here, we propose a star-shaped discrete block co-oligomer (BCO) platform to access carbohydrate nanostructures in bulk and thin-film states via the microphase separation of immiscible carbohydrate and hydrophobic blocks (maltooligosaccharides with 1-4 glucose units and solanesol, respectively). BCOs with various star-shaped architectures and saccharide volume fractions were synthesized using a modular approach. In the bulk, the BCOs self-assembled into common lamellar, cylindrical, and spherical carbohydrate microdomains as well as double gyroid, hexagonally perforated lamellar, and Fddd network morphologies with domain spacings of ∼7 nm. In thin films, long-range-ordered periodic carbohydrate microdomains were fabricated via spin coating. Such controlled spatial arrangements of functional carbohydrate moieties on the nanoscale have great application potential in biomedical and nanofabrication fields.",

author = "Takuya Isono and Ryoya Komaki and Nao Kawakami and Kai Chen and Chen, {Hsin Lung} and Chaehun Lee and Kazushige Suzuki and Ree, {Brian J.} and Hiroaki Mamiya and Takuya Yamamoto and Redouane Borsali and Kenji Tajima and Toshifumi Satoh",

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T1 - Tailored Solid-State Carbohydrate Nanostructures Based on Star-Shaped Discrete Block Co-Oligomers

AU - Isono, Takuya

AU - Komaki, Ryoya

AU - Kawakami, Nao

AU - Chen, Kai

AU - Chen, Hsin Lung

AU - Lee, Chaehun

AU - Suzuki, Kazushige

AU - Ree, Brian J.

AU - Mamiya, Hiroaki

AU - Yamamoto, Takuya

AU - Borsali, Redouane

AU - Tajima, Kenji

AU - Satoh, Toshifumi

PY - 2022/9/12

Y1 - 2022/9/12

N2 - Carbohydrates are key building blocks for advanced functional materials owing to their biological functions and unique material properties. Here, we propose a star-shaped discrete block co-oligomer (BCO) platform to access carbohydrate nanostructures in bulk and thin-film states via the microphase separation of immiscible carbohydrate and hydrophobic blocks (maltooligosaccharides with 1-4 glucose units and solanesol, respectively). BCOs with various star-shaped architectures and saccharide volume fractions were synthesized using a modular approach. In the bulk, the BCOs self-assembled into common lamellar, cylindrical, and spherical carbohydrate microdomains as well as double gyroid, hexagonally perforated lamellar, and Fddd network morphologies with domain spacings of ∼7 nm. In thin films, long-range-ordered periodic carbohydrate microdomains were fabricated via spin coating. Such controlled spatial arrangements of functional carbohydrate moieties on the nanoscale have great application potential in biomedical and nanofabrication fields.

AB - Carbohydrates are key building blocks for advanced functional materials owing to their biological functions and unique material properties. Here, we propose a star-shaped discrete block co-oligomer (BCO) platform to access carbohydrate nanostructures in bulk and thin-film states via the microphase separation of immiscible carbohydrate and hydrophobic blocks (maltooligosaccharides with 1-4 glucose units and solanesol, respectively). BCOs with various star-shaped architectures and saccharide volume fractions were synthesized using a modular approach. In the bulk, the BCOs self-assembled into common lamellar, cylindrical, and spherical carbohydrate microdomains as well as double gyroid, hexagonally perforated lamellar, and Fddd network morphologies with domain spacings of ∼7 nm. In thin films, long-range-ordered periodic carbohydrate microdomains were fabricated via spin coating. Such controlled spatial arrangements of functional carbohydrate moieties on the nanoscale have great application potential in biomedical and nanofabrication fields.

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AN - SCOPUS:85138081653

SN - 1525-7797

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JO - Biomacromolecules

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ER -

Tailored Solid-State Carbohydrate Nanostructures Based on Star-Shaped Discrete Block Co-Oligomers

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