Abstract
We synthesized chemically well-defined brush (i.e., comb-like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 °C and were readily solution-processable, yielding high-quality films. Interestingly, the brush polymers favorably self-assembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase-rich surfaces. The multibilayer-structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA-mimicking comb-like polymers are suitable as biomaterials and in protein separation applications.
Original language | English |
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Pages (from-to) | 1151-1160 |
Number of pages | 10 |
Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
Volume | 53 |
Issue number | 9 |
DOIs | |
State | Published - 1 May 2015 |
Keywords
- biocompatibility
- biomaterials
- biomimetic
- self-assembly
- synthesis
- thin films