Synthesis and self-assembly of DMPC-conjugated gold nanoparticles

Subhasish Chatterjee, Markrete Krikorian, Harry D. Gafney, Bonnie Gersten

Research output: Contribution to journalConference articlepeer-review

Abstract

Bio-conjugated nanomaterials play a promising role in the development of novel supramolecular structures, molecular machines, and biosensing devices. In this study, lipid-capped gold nanoparticles were synthesized and allowed to form a self-assembled monolayer structure. The nanoparticles were prepared by a phase transfer method, which involved the reduction of potassium tetrachloroaurate(I1I) by sodium citrate in an aqueous solution and the simultaneous transfer of the reduced species to an organic medium containing DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine). The gold nanoparticles were characterized using UV-Vis spectroscopy and dynamic light scattering (DLS) particle-size analysis. In addition, the resulting nanoparticles were examined using transmission electron microscopy (TEM). The Langmuir-Blodgett (LB) technique was used to assemble the DMPC-capped nanoparticles onto a water subphase at room temperature. The measurement of the compression isotherm confirmed the assemblage of lipid capped gold nanoparticles. This method of synthesis of ordered structures utilizing molecular interactions of lipids will be useful in developing novel metamaterials and nanocircuits.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalMaterials Research Society Symposium Proceedings
Volume1061
StatePublished - 2008
EventBiomolecular and Biologically Inspired Interfaces and Assemblies - Boston, MA, United States
Duration: 26 Nov 200730 Nov 2007

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