Surface plasmon spectral shifts of functionalized gold nanoparticles for the use in biosensors

Subhasish Chatterjee, Gina Moriarty, Bonnie Gersten

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Recently there has been a great interest in the use of gold nanoparticles to detect the hybridization process of DNA. The method uses the physical phenomenon that describes size-dependent Surface Plasmon Resonance (SPR) of gold nanoparticles and its shift to greater wavelengths upon their aggregation. Here we report on the synthesis of gold nanoparticles coated with functional linker biomolecules and their spectral shift driven by the formation of the avidin-biotin complex towards the use of these materials in the development of DNA biosensors. The gold nanoparticles were covalently functionalized by biotin and BSA-biotin in aqueous solution. UV-vis analysis of the dispersed colloidal nanoparticles resulted in a characteristic absorption spectra. Upon the addition of the avidin, the aggregation of gold nanoparticles was inferred from the alteration of absorption spectra.

Original languageEnglish
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages436-439
Number of pages4
StatePublished - 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: 7 May 200611 May 2006

Publication series

Name2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume2

Conference

Conference2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country/TerritoryUnited States
CityBoston, MA
Period7/05/0611/05/06

Keywords

  • Avidin
  • Biomarkers
  • Biotin
  • Gold nanoparticles
  • Surface plasmon resonance

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