TY - JOUR
T1 - Mechanisms of action of coffee bioactive components on lipid metabolism
AU - Farias-Pereira, Renalison
AU - Park, Cheon Seok
AU - Park, Yeonhwa
N1 - Publisher Copyright:
© 2019, The Korean Society of Food Science and Technology.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Coffee consumption is associated with reduced risk of metabolic syndrome, obesity and diabetes, which may be related to the effects of coffee and its bioactive components on lipid metabolism. Coffee contains caffeine, a known neuromodulator that acts as an adenosine receptor antagonist, as well as other components, such as chlorogenic acids, trigonelline, cafestol and kahweol. Thus, this review discusses the up-to-date knowledge of mechanisms of action of coffee and its bioactive compounds on lipid metabolism. Although there is evidence that coffee and/or its bioactive compounds regulate transcription factors (e.g. peroxisome proliferator-activated receptors and sterol regulatory element binding proteins) and enzymes (e.g. AMP-activated protein kinase) involved in lipogenesis, lipid uptake, transport, fatty acid β-oxidation and/or lipolysis, needs for the understanding of coffee and its effects on lipid metabolism in humans remain to be answered.
AB - Coffee consumption is associated with reduced risk of metabolic syndrome, obesity and diabetes, which may be related to the effects of coffee and its bioactive components on lipid metabolism. Coffee contains caffeine, a known neuromodulator that acts as an adenosine receptor antagonist, as well as other components, such as chlorogenic acids, trigonelline, cafestol and kahweol. Thus, this review discusses the up-to-date knowledge of mechanisms of action of coffee and its bioactive compounds on lipid metabolism. Although there is evidence that coffee and/or its bioactive compounds regulate transcription factors (e.g. peroxisome proliferator-activated receptors and sterol regulatory element binding proteins) and enzymes (e.g. AMP-activated protein kinase) involved in lipogenesis, lipid uptake, transport, fatty acid β-oxidation and/or lipolysis, needs for the understanding of coffee and its effects on lipid metabolism in humans remain to be answered.
KW - Alkaloid
KW - Cholesterol
KW - Fat
KW - Obesity
KW - Phenolic acid
UR - http://www.scopus.com/inward/record.url?scp=85070766079&partnerID=8YFLogxK
U2 - 10.1007/s10068-019-00662-0
DO - 10.1007/s10068-019-00662-0
M3 - Review article
AN - SCOPUS:85070766079
SN - 1226-7708
VL - 28
SP - 1287
EP - 1296
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 5
ER -