TY - JOUR
T1 - Is intraspecies QSTR model answer to toxicity data gap filling
T2 - Ecotoxicity modeling of chemicals to avian species
AU - Kar, Supratik
AU - Leszczynski, Jerzy
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10/10
Y1 - 2020/10/10
N2 - Interspecies model represents an established approach for the response data gap filling for regulatory agencies and researchers. We propose a novel approach of intraspecies modeling within the animals of the same species, instead of animals from different species. The proposed intraspecies model is capable of more precise extrapolation of data than the interspecies model, as animals under the same species share a similar mechanism of action (MOA) and target sites for the response. Along with the advantage of better prediction over the interspecies model, the intraspecies model has all the significant features like recognition of MOA, species-specific toxicity, reduction of animal experimentation, and money and time. To establish and test the intraspecies modeling approach, we have modeled ecotoxicity of organic chemicals to three avian species: Anas platyrhynchos, Colinus virginianus, and Phasianus colchicus. The intraspecies models offer to identify the mechanistic interpretation of the ecotoxicity of the studied chemicals along with the toxicity data gap filling. The success of the intraspecies modeling relies on connecting the missing dots of toxicity for the regulatory purposes, especially when there is a scarcity of ecotoxicity experimental data and in silico models for avian species.
AB - Interspecies model represents an established approach for the response data gap filling for regulatory agencies and researchers. We propose a novel approach of intraspecies modeling within the animals of the same species, instead of animals from different species. The proposed intraspecies model is capable of more precise extrapolation of data than the interspecies model, as animals under the same species share a similar mechanism of action (MOA) and target sites for the response. Along with the advantage of better prediction over the interspecies model, the intraspecies model has all the significant features like recognition of MOA, species-specific toxicity, reduction of animal experimentation, and money and time. To establish and test the intraspecies modeling approach, we have modeled ecotoxicity of organic chemicals to three avian species: Anas platyrhynchos, Colinus virginianus, and Phasianus colchicus. The intraspecies models offer to identify the mechanistic interpretation of the ecotoxicity of the studied chemicals along with the toxicity data gap filling. The success of the intraspecies modeling relies on connecting the missing dots of toxicity for the regulatory purposes, especially when there is a scarcity of ecotoxicity experimental data and in silico models for avian species.
KW - Avian
KW - Ecotoxicity
KW - Intraspecies
KW - QSTR
KW - Regulatory
UR - http://www.scopus.com/inward/record.url?scp=85085949409&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2020.139858
DO - 10.1016/j.scitotenv.2020.139858
M3 - Article
C2 - 32526407
AN - SCOPUS:85085949409
SN - 0048-9697
VL - 738
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 139858
ER -