Histamine and prostaglandins in schizophrenia: Revisited

It has long been accepted that schizophrenia is primarily a physical illness resulting from a chemical imbalance in the brain. This paper will review evidence supporting the hypothesis that histamine and prostaglandins are both linked and primary in the etiology of schizophrenia. Furthermore, their etiological significance supersedes the role of dopamine as a primary causative factor.