TY - JOUR
T1 - Epidemiology of intensive care unit-acquired sepsis in Italy
T2 - Results of the SPIN-UTI network
AU - SPIN-UTI network GISIO-SItI
AU - Agodi, Antonella
AU - Barchitta, M.
AU - Auxilia, F.
AU - Brusaferro, S.
AU - D'Errico, M. M.
AU - Montagna, M. T.
AU - Pasquarella, C.
AU - Tardivo, S.
AU - Arrigoni, C.
AU - Fabiani, L.
AU - Laurenti, P.
AU - Mattaliano, A. R.
AU - Orsi, G. B.
AU - Squeri, R.
AU - Torregrossa, M. V.
AU - Mura, I.
AU - Aiello, Mary Rose
AU - Alliani, Cristina
AU - Amatucci, Maria Rita
AU - Antoci, Manuela
AU - Antonelli, Massimo
AU - Astuto, Marinella
AU - Arnoldo, Luca
AU - Arru, Benedetto
AU - Baccari, Giorgio
AU - Barbadoro, Pamela
AU - Barbara, Andrea
AU - Barilaro, Cynthia
AU - Battaglia, Pietro
AU - Bellocchi, Patrizia
AU - Bernasconi, Mara Olga
AU - Bianco, Aida
AU - Bissolo, Emanuela
AU - Bocchi, Anna
AU - Bruno, Anna
AU - Brusaferro, Marco
AU - Buccheri, Margherita
AU - Campanella, Francesca
AU - Canino, Rosario
AU - Cannistrà, Antonino
AU - Carini, Santa Adele
AU - Catalano, Sebastiano
AU - Castellani, Paola
AU - Castiglione, Giacomo
AU - Coniglio, Salvatore
AU - Consolante, Ciriaco
AU - Conte, Carmela
AU - Contrisciani, Roberta
AU - Corallini, Rosy
AU - Crollari, Patricia
N1 - Publisher Copyright:
© 2018 Societa Editrice Universo.
PY - 2018
Y1 - 2018
N2 - Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.
AB - Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.
KW - Healthcare-associated infections
KW - Mortality Parole chiave: Infezioni correlate all'assistenza
KW - Mortalità
KW - Sepsi
KW - Sepsis
KW - Sorveglianza
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85055617180&partnerID=8YFLogxK
U2 - 10.7416/ai.2018.2247
DO - 10.7416/ai.2018.2247
M3 - Article
C2 - 30374508
AN - SCOPUS:85055617180
SN - 1120-9135
VL - 30
SP - 15
EP - 21
JO - Annali di Igiene Medicina Preventiva e di Comunita
JF - Annali di Igiene Medicina Preventiva e di Comunita
IS - 5
ER -