TY - JOUR
T1 - Distribution of CB2 cannabinoid receptor in adult rat retina
AU - López, Ester M.
AU - Tagliaferro, Patricia
AU - Onaivi, Emmanuel S.
AU - López-Costa, Juan J.
PY - 2011/5
Y1 - 2011/5
N2 - Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT-PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT-PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse, 2010. © 2010 Wiley-Liss, Inc.
AB - Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT-PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT-PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse, 2010. © 2010 Wiley-Liss, Inc.
KW - Cannabinoid receptor
KW - CB2
KW - Rat
KW - Retina
UR - http://www.scopus.com/inward/record.url?scp=79952229520&partnerID=8YFLogxK
U2 - 10.1002/syn.20856
DO - 10.1002/syn.20856
M3 - Article
C2 - 20803619
AN - SCOPUS:79952229520
SN - 0887-4476
VL - 65
SP - 388
EP - 392
JO - Synapse
JF - Synapse
IS - 5
ER -