TY - JOUR
T1 - Current status in the design and development of agonists and antagonists of adenosine a3 receptor as potential therapeutic agents
AU - Mailavaram, Raghu P.
AU - Al-Attraqchi, Omar H.A.
AU - Kar, Supratik
AU - Ghosh, Shinjita
N1 - Publisher Copyright:
© 2019 Bentham Science Publishers.
PY - 2019
Y1 - 2019
N2 - Adenosine receptors (ARs) belongs to the family of G-protein coupled receptors (GPCR) that are responsible for the modulation of a wide variety of physiological functions. The ARs are also implicated in many diseases such as cancer, arthritis, cardiovascular and renal diseases. The adenosine A3 receptor (A3AR) has emerged as a potential drug target for the progress of new and effective therapeutic agents for the treatment of various pathological conditions. This receptor’s involvement in many diseases and its validity as a target has been established by many studies. Both agonists and antagonists of A3AR have been extensively investigated in the last decade with the goal of developing novel drugs for treating diseases related to immune disorders, inflammation, cancer, and others. In this review, we shall focus on the medicinal chemistry of A3AR ligands, exploring the diverse chemical classes that have been projected as future leading drug candidates. Also, the recent advances in the therapeuetic applications of A3AR ligands are highlighted.
AB - Adenosine receptors (ARs) belongs to the family of G-protein coupled receptors (GPCR) that are responsible for the modulation of a wide variety of physiological functions. The ARs are also implicated in many diseases such as cancer, arthritis, cardiovascular and renal diseases. The adenosine A3 receptor (A3AR) has emerged as a potential drug target for the progress of new and effective therapeutic agents for the treatment of various pathological conditions. This receptor’s involvement in many diseases and its validity as a target has been established by many studies. Both agonists and antagonists of A3AR have been extensively investigated in the last decade with the goal of developing novel drugs for treating diseases related to immune disorders, inflammation, cancer, and others. In this review, we shall focus on the medicinal chemistry of A3AR ligands, exploring the diverse chemical classes that have been projected as future leading drug candidates. Also, the recent advances in the therapeuetic applications of A3AR ligands are highlighted.
KW - Adenosine a receptor
KW - Adenosine receptor
KW - Anti-inflammatory
KW - Bioactive heterocycles
KW - Immune disorders
KW - Neuroprotective
UR - http://www.scopus.com/inward/record.url?scp=85073124122&partnerID=8YFLogxK
U2 - 10.2174/1381612825666190716114056
DO - 10.2174/1381612825666190716114056
M3 - Review article
C2 - 31333098
AN - SCOPUS:85073124122
SN - 1381-6128
VL - 25
SP - 2772
EP - 2787
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 25
ER -