TY - JOUR
T1 - Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation
AU - Bai, Juan
AU - Farias-Pereira, Renalison
AU - Jang, Miran
AU - Zhang, Yuan
AU - Lee, Sang Mi
AU - Kim, Young Suk
AU - Park, Yeonhwa
AU - Ahn, Jun Bae
AU - Kim, Gun Hee
AU - Kim, Kee Hong
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
PY - 2021/1
Y1 - 2021/1
N2 - Purpose: Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown. Methods and Results: Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature. Conclusions: Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
AB - Purpose: Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown. Methods and Results: Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature. Conclusions: Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
KW - C. elegans
KW - azelaic acid
KW - fatty acid desaturation
KW - lifespan
UR - http://www.scopus.com/inward/record.url?scp=85100205224&partnerID=8YFLogxK
U2 - 10.1007/s11095-020-02975-w
DO - 10.1007/s11095-020-02975-w
M3 - Article
C2 - 33449249
AN - SCOPUS:85100205224
SN - 0724-8741
VL - 38
SP - 15
EP - 26
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 1
ER -