TY - JOUR
T1 - A HOME-BASED EXERCISE PROGRAM TO IMPROVE NEUROMUSCULAR AND SPATIO-TEMPORAL GAIT PARAMETERS IN A MULTIPLE MYELOMA CANCER SURVIVOR WITH CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
T2 - A CASE REPORT
AU - Marshall, Timothy F.
AU - Apicella, Elizabeth
AU - Herron, Sean
AU - Lacamera, Jonathan
AU - Koc, Thomas A.
N1 - Publisher Copyright:
© 2019 EdiSciences.
PY - 2019
Y1 - 2019
N2 - Introduction Chemotherapy-induced peripheral neuropathy (CIPN) may cause functional impairments such as gait or balance disorders, that increase fall risk. Gait disorders may be due to the neurotoxic effect of chemotherapy that causes a prolonged H-reflex latency and inability to inhibit spinal excitability (H-reflex), resulting in increased co-contraction of the lower extremity muscles. Purpose To assess the efficacy of a home-based exercise program on lower extremity muscle co-contraction, spatio-temporal gait factors, and fall risk in a multiple myeloma cancer patient undergoing chemotherapy and experiencing CIPN. Methods A case study was performed on a 67-year-old male diagnosed with multiple myeloma without achieving remission. The participant initially received 5 months of Velcade (bortezomib) which is when they began experiencing CIPN symptoms. The participant then underwent an autologous stem cell transplantation and is currently receiving darzalex, which the participant states exacerbates symptoms of CIPN. The participant has a history of falls secondary to CIPN. The participant initiated a home-based exercise program consisting of resistance, aerobic, balance, and stretching exercises two to three times per week. Outcomes were assessed at baseline and 4 weeks after initiating the exercise program. Results The participant demonstrated increased step length and velocity during gait. EMG data suggested improvements in activation timing and strength of the gastrocnemius and tibialis anterior throughout the gait cycle, as well as improvements in lower-extremity co-contractions. Conclusion This was the first study to investigate the efficacy of a home-based exercise program on lower extremity muscle activation timing and gait characteristics of a cancer patient with CIPN that is currently receiving chemotherapy. The present case study demonstrated that a home-based exercise program may be a feasible intervention to help reduce co-contractions and improve the activation times and amplitudes of lower extremity muscles, which may help improve spatiotemporal gait parameters and reduce fall risk.
AB - Introduction Chemotherapy-induced peripheral neuropathy (CIPN) may cause functional impairments such as gait or balance disorders, that increase fall risk. Gait disorders may be due to the neurotoxic effect of chemotherapy that causes a prolonged H-reflex latency and inability to inhibit spinal excitability (H-reflex), resulting in increased co-contraction of the lower extremity muscles. Purpose To assess the efficacy of a home-based exercise program on lower extremity muscle co-contraction, spatio-temporal gait factors, and fall risk in a multiple myeloma cancer patient undergoing chemotherapy and experiencing CIPN. Methods A case study was performed on a 67-year-old male diagnosed with multiple myeloma without achieving remission. The participant initially received 5 months of Velcade (bortezomib) which is when they began experiencing CIPN symptoms. The participant then underwent an autologous stem cell transplantation and is currently receiving darzalex, which the participant states exacerbates symptoms of CIPN. The participant has a history of falls secondary to CIPN. The participant initiated a home-based exercise program consisting of resistance, aerobic, balance, and stretching exercises two to three times per week. Outcomes were assessed at baseline and 4 weeks after initiating the exercise program. Results The participant demonstrated increased step length and velocity during gait. EMG data suggested improvements in activation timing and strength of the gastrocnemius and tibialis anterior throughout the gait cycle, as well as improvements in lower-extremity co-contractions. Conclusion This was the first study to investigate the efficacy of a home-based exercise program on lower extremity muscle activation timing and gait characteristics of a cancer patient with CIPN that is currently receiving chemotherapy. The present case study demonstrated that a home-based exercise program may be a feasible intervention to help reduce co-contractions and improve the activation times and amplitudes of lower extremity muscles, which may help improve spatiotemporal gait parameters and reduce fall risk.
KW - CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHYGAIT
KW - CO-CONTRACTION
KW - EXERCISE
KW - FALL
UR - http://www.scopus.com/inward/record.url?scp=85180486692&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85180486692
SN - 2704-6494
VL - 2
SP - 36
EP - 43
JO - Journal of Cancer Rehabilitation
JF - Journal of Cancer Rehabilitation
ER -